There are regular buses between Mopti and the nearby city of Sevare, as well as to the capital Bamako. As Sevare is on the main Road you may find it easier to travel there then catch a local bus to Mopti.
When the rivers are high, you can travel by boat to Mopti from both Timbuktu and Djenné.
Domestic flights also operate from Bamako and Timbuktu to Mopti.
